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J Gastroenterol Hepatol 31(2):403408 Strassburg CP (2010Oct 1) Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome)

Tiene la ventaja sobre el cido flico de que es la forma final y activa del folato, evitando el limitador en forma de enzima dihidrofolato reductasa (DHFR), que en el caso de las personas con su disfuncin hace que el cido flico no metabolizado a MTHF permanezca biolgicamente inactivo en el organismo [9,10 ,11]

However, in GCLM KO mice, genes encoding lipid synthesis enzymes, Fasn and Scd , were further down-regulated, whereas Fads1 was up-regulated by ethanol, the net effect of which would be expected to result in lower levels of total TG and increases in the relative abundance of certain lipid species

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