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Studies have suggested that Nrf2 is activated in the joints of arthritic mice and patients with rheumatoid arthritis, whereas Nrf2 deficiency is associated with accelerated arthritis development 44,45 , suggesting that Nrf2 might be a potential therapeutic target for OA

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In fact, it is believed that the French royal families who suffered from gout developed this condition more because of lead poisoning from the casks used for their wine than from the wine itself, since lead injures the kidneys and impairs their ability to remove uric acid from the system