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Preliminary studies have explored particles that shift from a negative to a positive charge upon permeating the barrier, facilitated by intestinal alkaline phosphatase cleavage of phosphate residues

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Phase 3 trials, which are larger and longer, are required to confirm these results and to establish long-term safety before approval

2.11.1 Therapeutic investigations Studies utilizing in vivo models have demonstrated the therapeutic efficacy of various natural compounds in targeting AD elated pathologies (Table 4)

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