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They are now approved again for use in humans by the FDA

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PLoS ONE 13 , e0195166 (2018)

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Procedural Treatments for Stubborn Melasma Procedures are important for melasma that does not respond to topical treatments

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In fact, lowered production of nitric oxide (NO) is considered one of the canonical features of the senescent endothelium [60]

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The pharmacological rationale for combining these two peptides centers on their complementary receptor targets

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