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Nature 324 , 7376 (1986)

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To study whether LC-induced p21 cip1 expression is associated with histone acetylation, the effect of LC on the acetylation of histone H3 associated with the p21 cip1 promoter gene was then examined by using ChIP

We observed partial inhibition of the autophagic flux in still asymptomatic 6-week-old Alms1 -/- mice, as well as signs of a more complete blockade in diseased 20-week-old Alms1 -/- animals