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2.3.3 Pathway inhibitors or activators In addition to iron and TLR agonist-based nanoparticles, some pathway inhibitors or activators can also target TAMs and polarize M2-type TAMs to M1-type TAMs, such as PI3K inhibitors, c-MYC inhibitors, NF-B and IRF5 activators

Online tools are available for calculating the theoretical pI of a protein EXPASY

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Estrogen Metabolism Support Optimizing hepatic Phase I and Phase II estrogen detoxification reduces the burden of potentially carcinogenic estrogen metabolites (particularly 4-OH and 16-OH estrone) and may reduce estrogen-driven fibroid growth: DIM (diindolylmethane): Shifts estrogen metabolism toward the favourable 2-OH pathway Calcium-D-glucarate: Inhibits -glucuronidase, preventing deconjugation and reabsorption of estrogens in the gut (Note: off-the-shelf detox kits from health food stores are not equivalent to therapeutic doses of these specific compounds) N-acetylcysteine (NAC): Supports glutathione synthesis and Phase II sulphation 3

Glutathione infusion assists in the transport of heavy metal ions such as mercury out of cells including your brain