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There have been reports of a potential signal for PD occurring after the administration of Ranibizumab to the vitreous humor of the eye during the treatment of retinal diseases such as macular degeneration related to age (AMD) (Sultana and Scondotto 2020)

Frank suggested oral tranexamic acid (yep, the same stuff in that serum, but in pill form)

Mitochondria are also involved in calcium and reactive oxygen species (ROS) homeostasis

Lea RA, et

However, this is not a fundamental limitation of the technique and perturbations such as inharmonicity can also be incorporated to handle phenomena such as stiff strings (Smith, 2010)