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[61] provided a final proof of concept

Their data indicated the importance of targeting the tumor microenvironment by blocking epigenetic mechanisms, which control critical events for colonization such as HGF/c-Met axis as a potential therapy of bone metastasis [40]

A Phase I/II Study of Pomalidomide and Dexamethasone with Growth Factor Support in Patients with Relapsed/Refractory Multiple Myeloma

Since L-dopa is converted to dopamine in the CNS and the peri phery, peripheral conversion and systemic effects can be reduced by combining L-dopa with carbi dopa (a peripheral decarboxylation inhibitor), which does not cross the bloodbrain barrier