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This may cause our pain system to overreact to movement and activity and cause excessive pain flare-ups even when the activity is not vigorous enough to injure our tendons

& Dichgans, J

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Pathways related to immunoglobulin, production, defense responses and B cell activation were among those downregulated, including immunoglobulin production ( IGKV112 , IGKV117 ), adaptive immune response (for example, CX3CR1 , FCGR1BP ) and B cell activation ( HDAC9 , CD180 , MNDA ) (Extended Data Fig