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doi: 10.1111/j.1365-3040.2009.01944.x 125 MittlerR

Anesth Analg 1978

Practical solution: reconstitute with less bacteriostatic water to create a smaller total volume, or accept that you will discard unused solution after 28 days and reconstitute a new vial

The pain message from the skin goes to the spinal cord and sends a signal right away to the muscle to contract

This suggests that activation of PXR by some drugs may be responsible for the acceleration of vitamin D breakdown through increasing CYP3A4 and CYP24, leading to vitamin D deficiency and, eventually, to bone loss [1]