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Conversely, autophagy appears to protect against apoptotic cell death by regulating proteins involved in both pathways, including Bcl-2 and Bcl-xL, and Beclin1 (Pattingre et al., 2005

1) Mechanistic gaps in crosstalk integration and novel regulatory nodes: Current research establishes a bidirectional link between ferroptosis and RF but lacks insights into the core molecular hubs that integrate this crosstalk