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The TCA product -ketoglutarate can be converted to glutamate, which is converted to glutamine by glutamine synthetase, an enzyme that is predominately, if not exclusively, located in astrocytes [20]

GSH depletion could lead to the overproduction of reactive oxygen species which can disrupt mitochondrial transmembrane potential and lead to mitochondrial dysfunction [32]

Adequate nutrition is crucial for maintaining the health of the mother throughout pregnancy and for the growth and development of the fetus

Exp Ther Med 20(1):173185

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