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Similar to GCL subunits, Nrf2 also is a positive regulator of GGT expression (Zhang et al., 2006)

The molecular mechanisms underlying berberine-induced cell cycle arrest include the increase of cyclin-dependent kinase (CDKs) inhibitors, such as p21 and p27, and the decrease of Cyclin D1 [215]

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GSTs conjugate 4HNE to GSH, and the corresponding glutathionyl-4-HNE (GS-HNE) is actively transported out of cells via RLIP76, a multifunctional membrane transporter for GSH-conjugated compounds, and/or MRPs (multidrug-resistance proteins