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The GCH1/BH4/DHFR axis operates independently of GPX4: guanosine triphosphate cyclohydrolase 1 (GCH1) catalyzes the rate-limiting step in the de novo synthesis of tetrahydrobiopterin (BH4) from GTP, producing BH4 as a potent radical-trapping antioxidant (RTA) that directly neutralizes lipid peroxyl radicals (LOO) and prevents membrane lipid peroxidation ( 2 ) a lipophilic radical-trapping antioxidant that detoxifies lipid peroxides where GPX4 access is limited

Eicosapentaenoic and docosahexaenoic acids attenuate progression of albuminuria in patients with type 2 diabetes mellitus and coronary artery disease

Traditional amino acid detection methods Traditional amino acid detection methods mainly include colorimetric method and high performance liquid chromatography (HPLC)

Osmolytes except urea function in maintaining the native folded conformation of proteins by increasing the near free energy of unfolded state of the protein (Khan et al., 2010)

Being able to point to the rare cell as the starting point to demonstrate the possibility of precommitment was the crucial stepping stone to providing evidence for the clonal selection theory (Lefkovits, Waldmann, June 2025)