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The Different Forms of B12 Not all B12 is the same

645 Transcriptome sequencing of neuropathic pain mice showed that TRIM28 is a crucial regulator of ferroptosis, and TRIM28 regulates iron homeostasis and ferroptosis in spinal microglia by downregulating GSK3 expression and regulating autophagy

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JW: Writing original draft

First of all, ferroptosis may be impacted by the overexpression of genes related to iron metabolism, such as HO-1, caused by the activation of HIF-1 in hypoxic environments (27)