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An update literature review in 2022 (search dates: 06/2013 01/2021) identified 63 studies, 53 of which were added to the evidence base The Panel judged that these were a sufficient evidence base from which to construct the majority of the treatment portion of the guideline and algorithm

Apart from the effects of these medications on vitamin B12 status, drugs that inhibit acid secretion have been observed to have negative impacts on the status of certain other micronutrients and the microbiome

Talk to your doctor immediately if you have trouble breathing, pain, itching, or bleeding at the site of the shot, severe stomach pain, an allergic reaction, depression, heavy bleeding, or other symptoms you're unsure about

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