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Moreover, SAMe and MTA treatment is also able to inhibit CRC migration, invasion and metastasis to the liver by increasing microRNA-34a/-34c/-449a expression, in a mechanism involving Notch signaling pathway inhibition [202,203]

Dopaminergic neurons are the core factories responsible for producing dopamine (DA), an unstable neurotransmitter that can cause oxidative toxicity in the iron-rich substantia nigra environment