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Because the heart and brain have high energy demands, they are particularly reliant on adequate CoQ10 levels

Besides, it is important to determine potential resistance mechanisms after inhibiting FSP1 for a long time and to identify deeper mechanisms associated with necroptosis medicated by FSP1 in more clinical cancer models

Tumor necrosis factor TNF- is a pivotal proinflammatory cytokine implicated in the pathogenesis and progression of PD

2.9.2 Animal models Female Balb/c mice (45 weeks) were purchased from Shanghai Laboratory Animal Center (SLAC, Shanghai, China) and bred in a sterilized, specific pathogen-free (SPF) Lab of Tongji University

The total GSH and GSSG contents were determined by the method proposed by Griffith [58] based on enzymatic recycling