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Histamine and saline were used as positive and negative controls, respectively

Research has shown that they selectively inhibit microsomal prostaglandin E synthase-1 expression in non-small cell lung cancer A549 cells, downregulate tumor necrosis factor-, inducible nitric oxide synthase, and anti-apoptotic factor B-cell lymphoma 2, and induce apoptosis in A549 cells (Toda et al., 2020)