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To increase the NADH/NAD + ratio, the citric acid cycle is very sensitive

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DOI: 10.1056/NEJMoa063070 Aaron SD, Vandemheen KL, Fergusson D, et al

In future perspectives, augmenting CAR-T cell efficacy, increasing resist immunosuppressive TME, overcoming antigen loss and heterogeneity, metabolic reprogramming, avoiding the CAR-T cell exhaustion and immunological synapse dysfunction, improving tumor site trafficking and infiltration, and importantly restricting the CAR, adverse events should be considered as major goals for researchers' efforts in this field