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Similar to the systemic calcium signal transmission upon GSH treatment, Glu-induced [Ca 2+ ] cyt propagation in systemic leaves were strongly inhibited in GCaMP3/glr3.3 while remained unaffected in GCaMP3/glr3.6 (Supplementary Fig

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As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

This effect is also dose-dependent [84]

The Trx system itself is a central hub of redox regulation, with its own redox status influencing numerous cellular processes beyond antioxidant defense