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M1 and M2 represent two phenotypes in macrophages with completely opposite functions, The former is characterized by high expression of pro-inflammatory cytokines, including IL-1, IL-6, IL-12, and TNF-, while the latter predominantly produces anti-inflammatory cytokines like IL-10 and TGF- (Shapouri-Moghaddam et al., 2018)

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While mild soreness is expected after a vaccine, persistent arm numbness may indicate nerve irritation or an immune reaction.

Qiu X, Wang A, Wang J, Zhang Z, Tao L (2025) Mitochondrial metabolic reprogramming in colorectal cancer, mechanisms of resistance and future clinical interventions