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They suppress the proinflammatory gene expression and toll-like receptors and inhibit the enzymes required for producing eicosanoids

ShahwanM, Hassan N, Noshi A, PREVALENCE AND RISK FACTORS OF, VITAMIN B12 DEFICIENCY AMONG PATIENTS WITH TYPE II DIABETES ON METFORMIN: A STUDY FROM NORTHERN REGION OF UNITED ARAB EMIRATES (2018) Asian J Pharm Clin Res 11:225229

doi: 10.1016/J.HORIZ.2024.100090 33

Iron-binding proteins and free iron in synovial fluids of rheumatoid arthritis patients

The analysis uses LC-MS/MS (liquid chromatography tandem mass spectrometry), a technique that detects these compounds at parts-per-trillion sensitivity, significantly more precise than ELISA-based antibody tests