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Indeed, homocysteine neurotoxic properties have been attributed to NMDA receptor stimulation, auto-oxidation elevating oxidative stress, mitochondrial complex I inhibition, and allosteric D2 receptor antagonism (88)

In rats with collagen-induced arthritis (CIA), BM-MSC transplantation has been shown to inhibit the expression of cytokines associated with bone destruction, alleviate joint inflammation, and inhibit synovial proliferation and cartilage destruction

To investigate the function of CBS in this process, we silenced its expression by CRISPR/cas9 mediated gene knockout strategy (sg CBS ) in SCD erythroblasts (Fig

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