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Acknowledgements This research was supported in part by AMED-CREST, by JST, PRESTO, by MEXT/JSPS KAKENHI grant numbers JP16H02606 and JP26111012 (to Y.U.), JP15H05951 Resonance Bio (to M.K.), by JSPS Core-to-Core Program, by a grant from Hoansha Foundation (to Y.U.)