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Information sources and search strategy Three databases (PubMed, Embase, and Scopus) were searched up to 15 July 2024

All studies with cancer patient receiving either anti-PDL1/anti-PD1 alone or in combination with anti-CD38 were included

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Byproducts caused by bromine When bromine exists in water, bromine will be oxidized into hypobromous acid by ozone, and then hypobromous acid will be oxidized into bromate, which has carcinogenicity to human body [ 67 ]