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78 Apart from its significant impact on DNA damage, redox signaling can also influence the repair status of DNA damage by finely regulating the redox modifications of DNA repair-related proteins (Fig

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Laurell and Eriksson observed in 1963 that individuals with a hereditary deficiency of the serum protein alpha-1 antitrypsin, which inhibits a number of serine proteinases such as neutrophil elastase, are at increased risk of developing emphysema 62