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Persistent hyperglycemia in diabetes induces oxidative stress via mitochondrial dysfunction and subsequent enhanced reactive oxygen species (ROS) production

Finally, we outline translational prospects, arguing that targeting this pathway will require precision medicine strategies, including composite biomarkers and rational combination therapies

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MTs are cysteine-rich proteins that regulate Zn and copper homeostasis, are involved in heavy metal detoxification (such as cadmium and mercury), alleviate oxidative/nitrosative stress, and participate in immune responses [331]