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FAO substrates are derived from the external environment via specific transporters able to mediate fatty acid uptake, such as CD36 (Figure 3)

Specifically, research shows that Bifidobacterium adolescentis is a high GABA producer.[ref] Lactobacillus brevis DPC6108 and Lactobacillus rhamnosus are also probiotic strains that produce GABA.[ref][ref] A 2024 double blind placebo controlled trial found that a probiotic formulation of Lactobacillus brevis and Lactiplantibacillus plantarum reduced symptoms of depression and improved mood, but did not affect stress levels

By suppressing these inflammatory mediators, curcumin contributes to reducing hepatic inflammation and may prevent the progression to more severe forms of liver disease, such as NASH

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