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However, this HIF-dependent metabolic rewiring also impairs fatty acid oxidation, resulting in pathological lipid accumulation, therefore providing a HIF-dependent molecular basis for diseases characterized by fat accumulation such as liver steatosis or obesity

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AMPK acts as a core regulator of ATP balance in cells and can have diametrically opposite effects on substrate-dependent ferroptosis

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Evid Based Complementary Altern Med 4:2931 Makarova MN, Pozharitskaya ON, Shikov AN, Tesakova SV, Makarov VG, Tikhonov VP (2007) Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats