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Third, the concept that EMT can be reversed is still debated, given the paucity of direct in vivo evidence (123), with some studies suggesting the occurrence of mesenchymal-to-epithelial transition (MET), whereas others argue that fibrosis resolution is mainly driven by myofibroblast apoptosis rather than phenotypic reversion (124)

10.1016/j.jnutbio.2012.01.010 J Nutr Biochem

In contrast to the control group, the HFD/STZ-induced T2DM rats exhibited a marked reduction in plasma insulin levels, accompanied by a concomitant increase in HOMA-IR, indicative of insulin resistance

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Sharma, S.S