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J Thorac Cardiovasc Surg 165(1):398-400, 2023

Oral administration of the probiotic Pediococcus pentosaceus SMM914 (SMM914) can enhance the abundance of gut probiotics and strengthen the tryptophan-melatonin pathway, increasing endogenous anti-inflammatory factors such as 6-hydroxymelatonin and secondary taurine in the lung environment, reducing the polarization of macrophages to the M1 phenotype, and finally alleviating oxidative stress in COPD mice (69)