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Genomic and transcriptomic analyses of breast cancer primaries and matched metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative

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The question researchers keep returning to is whether restoring GH pulsatility in aged subjects reverses measurable functional decline in muscle, bone, and metabolic parameters, or whether the somatopause itself reflects a broader neuroendocrine recalibration that GH restoration cant fully address

One study found that MS patients had higher levels of Akkermansia and Acinetobacter and lower Parabacteroides compared to controls, and when these microbial communities were transferred to germ-free mice, the mice developed more severe EAE (the mouse model of MS) [184]

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