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3rd group with abnormally lowed mitophagy levels Abnormally low cf-mtDNA levels in the tear fluid may indicate mitochondrial burn-out associated with impaired energy production and highly increased cellular stress

furthermore, NET inhibitors repressed NET formation and reduced M1 macrophage markers in a mouse model of acute lung injury (Song et al., 2019)

Also, when HHcy is present in atherosclerotic patients, protein homocysteinylation is enhanced (109)

25 Thus, high levels of aldehyde dehydrogenase in the liver, early hematopoietic cells, and intestinal stem and mucosal absorptive cells are consistent with reduced hepatic, gastrointestinal (GI), and hematopoietic toxicities associated with cyclophosphamide as compared to other alkylating agents

Monitoring the injection site for 24-48 hours for any concerning symptoms including increasing redness, swelling, pain, or warmth that might indicate infection