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The Nrf2 dissociation from Keap1 blocks the E3 activity of the Keap1 complex, stabilizes Nrf2, and promotes its nuclear accumulation, which initiates anti-ROS gene expression and contributes to cell survival in the stress

Qian H, Zhu M, Tan X, Zhang Y, Liu X, Yang L

Acrolein Acrolein is a highly reactive aldehyde used in the synthesis of several organic compounds in chemical industry and as a biocide in agriculture