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Among the most striking observations was a downregulation of glycolysis in cetuximab and combo-treated cells at early time-points, while proteins related to iron metabolism, such as ferritin and transferrin receptor TFRC, were respectively up and downregulated in VitC and combo-treated cells at later time-points

However, when analyzing the results of three randomized clinical trials (RCTs), the impact of magnesium supplementation on IR in these women was variable