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For example, tumor cells may avoid the effect of drugs by changing their metabolic pathways, such as surviving by upregulating alternative amino acid metabolic pathways after using HIF-2 inhibitors, or resisting the oxidative stress caused by treatment by enhancing specific metabolic pathways (such as the synthesis of antioxidant glutathione) ( 5.3 Insufficient evidence in the real world and the urgent need for cross-centre standardisation There are still two core obstacles to translating findings on metabolic reprogramming into clinical practice

Treatment focuses on addressing the underlying cause, controlling symptoms, and preventing complications particularly foot injuries in patients with diabetes who cannot feel pain normally

PMID 34288673