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PubMed PMID: 30892761

4 The significance of bilirubin in clinical practice and prognostic models derived from it The above article describes the association of bilirubin with some cancers, which naturally leads to the question of whether bilirubin can be used as a way to optimize bilirubin-related cancer treatment and patient stratification, but it has been shown that, while individual serum markers are useful prognostic factors in the study of patients with cancer, individual markers may not be sufficient for predicting survival in the clinical setting

Furthermore, lysosomal cell death mediated by signal transducer and activator of transcription 3 (STAT3) contributes to ferroptosis through increased cathepsin expression and activity (Wen et al., 2019)