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Phenylalanine, tryptophan, and tyrosine act as precursors to neurotransmitters including dopamine and serotonin [55]

[4] Like glycolysis, the pentose phosphate pathway appears to have a very ancient evolutionary origin

Liver biopsies from MASH patients and M1 macrophage with the PNPLA3 I148M variant revealed reduced PGC1-alpha, NRF1/2, mt-ND1, and 16sRNA mRNA transcripts compared to wildtype