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For instance, the addition of ganitumab, a monoclonal antibody targeting IGF-1R, to carboplatin/paclitaxel chemotherapy in patients with primary epithelial ovarian cancer did not improve progression-free survival in a phase II multicenter controlled trial (65), despite the promising results of IGF-1R inhibition in various preclinical studies (25, 32, 64)

Xanthine oxidase, another FAD-dependent enzyme, catalyzes the oxidation of hypoxanthine and xanthine to uric acid

Choose multi-strain formulations with at least 10 billion CFUs for optimal effectiveness

The suppression of PDCD4 correlates with higher Gleason scores and promotes androgen-independent growth of PCa tumors [117]

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