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Clin Cosmet Investig Dermatol 24:5157 Tagliaferri V, Romualdi D, Scarinci E, Cicco SD, Florio CD, Immediata V, Tropea A, Santarsiero CM et al (2018) Melatonin treatment may be able to restore menstrual cyclicity in women with PCOS: a pilot study

However, there are some limitations to every study

Nat Immunol (2017) 18:48898

Any friction and inflammation repeatedly applied leads to the skin under your underarms darkening over time

These comprise both hepatic and extrahepatic conditions, including portal hypertension in cystic fibrosis, porto-sinusoidal vascular disease, malignant mesothelioma, incident type 2 diabetes (T2D), cardiovascular disease risk, metabolic syndrome, fibrosing NAFLD, chronic kidney disease (CKD), neurodegenerative disorders and dementia, idiopathic pulmonary arterial hypertension, and Corona Virus Disease 2019 (COVID-19)