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Notably, imaging and flow cytometric analysis with acridine orange as a pH sensor revealed that treatment with RSL3 for 3 h increased lysosomal pH, which was effectively prevented by treatment with lysosomal LPO inhibitors, including Lip-1, NBD-Pen, and Lyso-NBD-Pen (Lyso-NP) (Fig

doi:10.1128/msystems.00001-18 88

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Many peptides were restricted to "Category 2" of the 503A bulks list in 2023 (barring compounding), and in early 2026 HHS signaled that roughly 14 of them could move back toward compoundable status, with an advisory committee review mid-2026