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10.1007/s00401-016-1545-1 65 LouisD

Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors

In univariate analysis SHUNT% was the strongest single predictor of new clinical decompensation, liver-related death, or liver transplantation (n=13 with clinical outcomes, AUROC 0.886 for V1.1, 0.853 for V2.0, and 0.834 for LDT 1.0) with no significant differences in operating characteristics between Test versions

P.DharmarajN.CarsonD

investigated the role of the cytochrome P450 enzyme CYP1B1 in Mn-induced toxicity using in vitro experiments with human cerebral microvascular endothelial cells (hCMEC/D3), an in vitro model of the BBB [141]