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Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells

A decrease in SOD2 leads to the accumulation of ROS in mitochondria, which in turn disrupts membrane potential and inhibits respiratory chain activity, forming a vicious cycle of ROSmitochondrial damagemore ROS

The basic requirement for this, however, is that all building blocks must be present, otherwise a glutathione deficiency can occur

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For example, Berk et al (217) revealed notable improvements in negative symptoms as measured using the Positive and Negative Syndrome Scale in patients treated with NAC as an adjunct to their ongoing antipsychotic regimen