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Proliferating bacteria metabolize a large amount of cysteine and glutathione, and the substrate required for GPX4 is depleted by rapidly growing bacteria ( 3.2.2 Ferritinophagy Attenuated Salmonella infection simultaneously activates NCOA4-dependent ferritinophagy ( 3.3 Autophagy and apoptosis 3.3.1 Autophagy: the balance between survival and death Autophagy plays a dual role during attenuated Salmonella infection

Trends Endocrinol Metab (2017) 28(3):18698

Over activation of glutamate receptors and the resulting Ca 2+ overload stimulates calpains which target cytoskeletal proteins, kinases and phosphatases, membrane receptors and transporters (Xu et al., 2009

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Then we computed using our model whether the functional hepatocytes ever declined below 30% in which case we predict death rather than recovery