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Community Register of orphan medicinal products from the European commission: Orphan Drug Designations and Approvals from the FDA: ClinicalTrial.gov to retrieve the list of clinical trials for WS: Additional Drug RepurposingBased Therapeutic Strategies Under Investigation GLP-1 analogs also appear as a promising therapeutic opportunity for Wolfram syndrome (Table 3)

Anemia caused by a lack of vitamin B12 is usually curable with diet and vitamin supplementation or injections

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While controlled activation of HIF-1 (e.g., via PHD inhibitors like DMOG) can enhance early healing and angiogenesis, chronic or unregulated activation promotes fibrosis, ECM disorganization, and persistent inflammation (Wu et al., 2018

Integrated analysis of concomitant medications and oncological outcomes from PD-1/PD-L1 checkpoint inhibitors in clinical practice