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The rate of progression is significantly rapid in the first few years of undetected or misdiagnosed RA ( Furthermore, patients with RA generally complain of gastrointestinal tract problems particularly dyspepsia (bloating, postprandial fullness, nausea, early satiety, epigastric pain, and burning and belching), mucosal ulceration, and altered bowel habits (constipation/diarrhea) (27)

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

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If IV therapy is not covered, patients may need to pay out-of-pocket, and many clinics offer payment plans or financing options to make treatments more affordable