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Phosphoribosyl pyrophosphate synthetase 1 (PRPS1), the key enzyme of the de novo nucleotide synthesis pathway, is O -GlcNAcylated by O -GlcNAc transferase (OGT), which triggers PRPS1 hexamer formation and relieves nucleotide product-mediated feedback inhibition, thereby boosting PRPS1 activity

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FIGURE 2 7.1.2 Reducing systemic inflammation Patients with pulmonary function impairment often experience systemic inflammation, which not only further affects lung function but can also lead to other complications (Sungurlu and Balk, 2024), while promoting the release of anti-inflammatory cytokine IL-10 to help reduce the inflammatory response (Sleijser-Koehorst et al., 2023

While some users report transient euphoria and increased self-confidence, others experience negative emotional states, including irritability, sadness, or heightened aggression ( Given the complexity of these interactions and the limited number of high-quality longitudinal studies, further research is warranted to better characterize the psychological consequences of anabolicandrogenic steroid use in amateur sports and to inform effective prevention and clinical management strategies

However, the beneficial effect was not replicated in the larger and more stringently performed phase III EMBODY trial (25)