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Hyperglycemia decreases glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in bovine aortic endothelial cells via the increased production of mitochondrial superoxide and a concomitant increase in hexosamine pathway activity [7,8]

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The next generation of nanomedicines should be designed to be safer, more selective, and more therapeutic, targeting the real degenerative triggers with reduced adverse effects (217)

Koprivica I, Vujii M, Gaji D, Saksida T, Stojanovi I (2019) Ethyl pyruvate stimulates regulatory T cells and ameliorates type 1 diabetes development in mice

In a Cochrane's study (72), the efficacy of probiotics on acute infectious diarrhea in subjects of all ages was studied and a reduction in the duration of diarrhea by 1 day was demonstrated