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Liver (hepatic) and kidney safety considerations are equally important, since some supplements that undergo hepatic metabolism or renal excretion can accumulate or interact with chemotherapeutic drugs leading to hepatotoxicity (e.g., kava, high-dose green tea extract) or nephrotoxicity in patients who already suffer from impaired organ function or taking chemotherapy agents known to be nephrotoxic such as cisplatin (208, 209)

This EV-mediated transfer of mtDNA may amplify neuroinflammatory responses by activating PRR in recipient cells, thereby facilitating the spread of pathological signals across neural networks

Among the genes downregulated by more than 1.4-fold, a significant enrichment of functional pathways related to caveola, cytoskeleton organization, blood vessel and coagulation, as well as chromosomal proteins was observed

Eosinophil-epithelial cell interactions in asthma

Urolithin A induces mitophagy and prolongs lifespan in C